NASA astronaut Kate Rubins, cosmonaut Anatoly Ivanishin of the Russian space agency Roscosmos, and astronaut Takuya Onishi of the Japan Aerospace Exploration Agency are now in orbit and this is the first flight for the upgraded Soyuz MS-01 spacecraft.
The crew unites Russian cosmonaut Anatoly Ivanishin, Japanese astronaut Takuya Onishi and NASA astronaut Kathleen Rubins.
The three new crewmembers are scheduled to remain on the station for about four months, and they will be joined toward the end of September by NASA astronaut Shane Kimbrough and Russian cosmonauts Andrey Borisenko and Sergey Ryzhikov.
The Soyuz spacecraft is due to dock with the International Space Station at 0412 GMT on July 9.
The trio will spend their two-day journey testing the modified systems of Soyuz MS-01 spacecraft, before they finally dock the ISS on July 9, Saturday.
Expedition 48 crew members are expected to receive and install the station's first global docking adapter, which will accommodate future arrivals of USA commercial crew spacecraft.
'I'm incredibly excited about a lot of the biology experiments we're going to be doing, ' she said in an interview before launch.
However, the new Soyuz series is supposed to have upgraded and redundant thrusters, an additional micrometeoroid debris shielding, solar cells to increase power capacity, an ungraded rendezvous antenna system, and an improved navigation system.
Flight Engineer Ivanishin has already logged over 165 days in space following his first mission at the ISS in 2011 and 2012.
For the 37-year-old Rubins, the space station journey is the culmination of a dream that began during her childhood in Napa with frequent stargazing nights and a trip to the NASA Space Camp in Huntsville, Alabama.