The deal includes $40 million guaranteed to Mathieu, making him the highest paid defensive back in the game ahead of Josh Norman and Darrelle Revis.
In spite of that, Arizona is stepping up to retain a player who has excelled at the National Football League level.
Mathieu's first contract had $800,000 guaranteed with a multitude of drug tests, but much of the money was spread over four seasons because of concerns about his earlier problems.
- Ian Rapoport (@RapSheet) August 2, 2016 The #AZCardinals have been clear on this: They wanted to reward Tyrann Mathieu & pay him what he's worth.
A dynamic defensive back at LSU, Mathieu was a Heisman Trophy finalist as a sophomore in the 2011 season, the first defensive back so honored since Charles Woodson won the award in 1997.
Now that Mathieu's under contract for the next five years, the Cardinals will be hoping that he can stay healthy.
Mathieu is now recovering from an ACL tear he suffered in last season's game against the Philadelphia Eagles.
Back in January, Mathieu told reporters, "I think this is the flawless place for me".
Mathieu's contract will average $12.5 million per season, which surpasses the $10.8 million Eric Berry will make with the Kansas City Chiefs this season under the franchise tag.
Just minutes before the news came down, Honey Badger took to Twitter and had one short thing to say and it was likely in response to his huge contract. He recorded five interceptions with a touchdown, 80 tackles and 17 pass deflections. He was also named to the Pro Bowl. ESPN's Adam Schefter reported that the deal is for five years at, $62.5 million.