It will be their first whitewash against a side, in a bilateral series, if they manage to win at Cardiff.
The lowest strike-rate of an England player in the XI at Headingley - when the match was completed - was David Willey's 81.17.
The two teams were forced to stay away from the rain-soaked ground on Saturday, instead opting for indoor nets sessions ahead of the fifth and final game of the series.
Mohammad Irfan's fitness issues meant a return for Mohammad Amir after missing the Headingley defeat, while Pakistan also brought back Shoaib Malik at the expense of Sami Aslam, with Azhar returning to opener.
Irfan, who was called into the squad after Mohammad Hafeez was ruled out, had started promisingly on his return, removing Alex Hales and Jason Roy during a lively five-over opening spell, and also troubled Eoin Morgan. "He returned to play and later on complained about cramps in his left and right calf that prevented him bowling further in the match", the PCB was quoted as saying by ESPNcricinfo.
In that match, half-centuries from Ben Stokes and Jonny Bairstow saw the hosts recover from 72-4 to successfully chase down their target of 248 with two overs to spare.
This is a scenario that will frighten both their legions of loyal fans and ICC chiefs who could see their showpiece tournament deprived of a money-spinning match between Pakistan and arch-rivals India.
Pakistan's innings was anchored by Azhar Ali's 80 off 104 balls, while Imad Wasim was again impressive with an unbeaten 41-ball 57, however the tourists struggled to shake off the shackles that England had imposed on them.
By then, irrespective of this weekend's outcome, Azhar is confident they will be able to show the benefits of their tough learning curve.
"England are a phenomenal cricket team, power-hitters all the way down".
Mickey Arthur, the Pakistan coach, did not hide his frustrations in the dressing room but later defended Irfan's call-up despite his very limited recent cricket, insisting that "checks and balances" had been in place.
"Where we are lacking as a batting unit we are not rotating the strike and we don't have the guys who can clear the ropes".
"It is what it is", said Arthur, who only took over as Pakistan coach in May.
"I look at the strikers England have at their disposal - it's unbelievable".
"There is still a decision to be made but at the same time I'm pretty confident in the decision that I will make and that it will be a positive one if selected, because the squads haven't been announced".
Pakistan hit back late through its seamers to restrict England's total with Hasan Ali grabbing 4-60 and Mohammad Amir taking 3-50.
Pakistan's tour ends with a lone Twenty20 worldwide against England at Manchester's Old Trafford on Wednesday.