Her approach in her first Conservative Party closing speech as Prime Minister strikes a significant different tone to her predecessor David Cameron, who in his early days in Downing Street called for communities to be liberated from "wasteful, top down government" and the creation of the "Big Society".
She said there would be "bumps in the road" as Brexit happens, but insisted she would be "ambitious" in negotiating a deal with the remaining European Union members.
That put it below levels it hit in the immediate wake of the June 23 referendum in which Britain voted to leave the EU.
"We desperately need a plan which delivers for working people, but the Tories have no answer to the challenges facing us".
May told the Conservative Party's annual conference that she would govern from "the new center ground of British politics, built on the values of fairness and opportunity".
The urgency for talks with the eurosceptic ministers has increased after Prime Minister Theresa May said on Sunday that she would trigger the process to leave the European Union by the end of March.
Sterling was also down 0.2 per cent against the euro at 1.14.
"I am going to be ambitious as we go into discussions", she said.
Britain's allies fear its exit from the EU could mark a turning point in post-Cold War worldwide affairs that will weaken the West in relation to China and Russian Federation, undermine efforts towards European integration, and hurt global free trade. Even smaller British companies focused on the local economy are gaining thanks to recent upbeat economic indicators and the central bank's recent move to cut interest rates. The EU has long insisted Britain can not be part of the common market if it blocks EU workers.
But she said she wanted a deal that worked for Britain and British businesses, and also allowed European businesses to deal with Britain.
But last night, a senior member of the EU's negotiating team warned Mrs May that no formal Brexit negotiations will take place until after she has triggered Article 50.
"The great danger is that we don't get as good a deal on trade because we obsess about controlling immigration", Soubry said. But she said the United Kingdom would not cede control over immigration, a conflict with the EU's principle of free movement that could prove a sticking point in negotiations.
The conference has seen the ruling party announce a range of policies created to appeal to Labour voters as well as the supporters of the right-wing U.K. Independence Party.