Saying that USA is not at war with Islam, Mrs Clinton said, as President she will not let anyone into the country who she thinks poses a risk to America, but a lot of refugees, mostly women and children, can not be refused entry just because they are Muslims.
Some of the tweets were serious, pointing out injustices that Muslims face everyday. "Muslims have to report the problems when they see them", he said. Some say they saw one pacing the debate stage tonight.
When questioned about his plans for "a total and complete shutdown" of foreign Muslims entering the United States alongside the issue of Islamophobia, Trump explained that the proposal to ban Muslims from entering the country has "morphed" into a plan for "extreme vetting" of refugees.
"He and I haven't spoken and we don't agree", Trump said when moderator Martha Raddatz pointed out that the position he had laid out differed from Mike Pence's opinion that U.S. military strikes may be necessary in the war-torn country.
It wasn't just about Trump's comments though.
Clinton had said, "We need American Muslims to be part of our eyes and ears on our front lines".
Kumail Nanjiani, star of HBO's "Silicon Valley", chose to report his assessment of the cinematic merits of "Gremlins 2".
And because the debate wasn't the only thing going on last night, others reported weather updates and culinary tips.
"Muslim here. I am eating ice cream now".
His comments were met with much disgust from Clinton: "We are a country founded on religious freedom and liberty".