Messi took just three minutes to score on his return from a groin injury as a substitute in Saturday's 4-0 win over Deportivo la Coruna.
Meanwhile, Liverpool are the only English team to beat Barcelona at the Nou Camp in the Champions League, back in 2007.
Former Barca boss Guardiola takes his City side to the Nou Camp on Wednesday for the first of two eagerly-anticipated meetings between the clubs in Group C of this season's competition.
MANCHESTER, ENGLAND - OCTOBER 15: Josep Guardiola, Manager of Manchester City gives his team instructions during the Premier League match between Manchester City and Everton at Etihad Stadium on October 15, 2016 in Manchester, England.
There are some good news for Luis Enrique as well.
"I hear a lot of times about that intensity of the Premier League when none of you have been in La Liga or the Bundesliga to know how intense it is", Guardiola replied.
"I didn't call any players on the phone - there are those that are lost before they've even started", Guardiola said. This is the sort of game which the young defender left Everton to play in and, if he's at his best, this could be a game which really makes him.
Profits almost doubled to 20.5 million pounds ($25 million) in the 2015-16 season, when the only trophy was the League Cup, prompting the replacement of Manuel Pellegrini as manager with Pep Guardiola.
Spanish media reports ahead of the blockbuster fixture claimed Guardiola attempted to coax some of Barca's leading lights to Manchester, including Messi, Luis Suarez, Sergio Busquets and Andres Iniesta.
"I've not spoken to Pep", Enrique said.
"The amount of unavailable players is tough to deal with but the squad is big enough - now other players have to step in", said sporting director Max Eberl after it was revealed that Fabian Johnson (illness), Andreas Christensen (gluteal), Raffael (thigh) and Thorgan Hazard (knee) had joined an already-lengthy injury list. "It's good that Barca are still recognised for being an attractive team and for a philosophy of attacking football".
Pep Guardiola's intimate knowledge of Barcelona can help Manchester City at Camp Nou but Pablo Zabaleta knows they face a formidable task.
However, Luis Enrique does not expect those games to provide a template for Wednesday's clash. The former player and manager of the Catalunyan side holds a deep affinity with the club, and will no doubt see tomorrow's game as his City side's biggest of the season so far.
"I think Manchester City is a different team from last year or the years they came here with (Manuel) Pellegrini", added the former Manchester United man. David Silva and Kevin De Bruyne will always play, arguably City's best players and they'll be needed at their best.
"Our aim was to surprise them and it worked how we wanted it to". It's an attractive game.
Samuel Marsden covers Barcelona for ESPN FC.