While the issues concerning Aguero and Bravo commanded the City-focused headlines on Wednesday, the absence of captain Vincent Kompany received relatively little attention.
The City boss has failed to win any of his last four games and was beaten 4-0 by Barcelona in the Champions League on Wednesday.
Kompany has struggled with injuries in recent seasons while Aguero has often been linked with a return to Spain's La Liga.
Guardiola dismissed out of hand the link between their absence from the starting line-up and being considered surplus to requirements. He went to the doctors in Barcelona and said I'm not able to play.
"Next time, before you give this opinion, you can call me".
"I thought in the last 30 minutes, with the Barcelona center-halves tiring, he could help a lot from the bench".
"Vincent was not perfectly fit".
Kompany was surprisingly left out of the squad of 18 in the Nou Camp in midweek after admitting he didn't feel right mentally, despite being physically fit. "For me, (there was) no big difference between the two teams", Puel told reporters on Friday. I think City are playing a good game and had good style against Barcelona.
Kompany would appear the more vulnerable of the two players given the amount of time he has spent on the treatment table.
They will seek to end a four-match winless run when they host Southampton on Sunday, but even if they lose Guardiola said he will not be adapting the philosophy that has served him so well throughout his career.
"I've never trained with him in the past", he said.
Barcelona will once again lock horns with City on November 2.
What's also odd is that last week Joe Hart put in one of the best performances we've seen from him as England drew 0-0 with Slovenia, so seeing Claudio Bravo continually mess up must having him scratching his head - although I don't think he'll be getting pleasure from it.
Per Simon Bajkowski and Ciaran Kelly of the Manchester Evening News, he added: "I think about [changing] but after that the solution is not better than what I believe". If one of your defenders does that you'd be critical of them, particularly for your goalkeeper and as I said there's a time and a place and there's a time to clear your lines.
The scoreline finished 4-0 in Barcelona's favour, but it wasn't a game that Barcelona were particularly good or that Manchester City were particularly bad. If we lose I'm guilty, if we win I'm a genius. You want a guilty? "I'm sure the goals will come, I just need to keep persisting to be on the field". I am a genius. "We are a club that for 35 years was not in Europe".