The airline said that roughly 215,000 passengers would be affected by the cancellations on Wednesday and Thursday, which include more than 130 intercontinental flights. Yesterday evening (Tuesday), Lufthansa pilots launched an enormous strike, grounding a third of the airline's planes. Austrian and SWISS are using larger planes to carry passengers during the strike, while Lufthansa has reserved nearly 4,000 hotel rooms in Frankfurt and Munich for stranded passengers.
The Vereinigung Cockpit pilots' union first organized a one-day strike on Wednesday, but after Lufthansa was rejected twice in court trying to stop it, the union extended the walkout to two days.
The statement added: "Lufthansa has offered the union a joint request for mediation, because this labour dispute can only be resolved if a compromise can be found together".
A Lufthansa flight scheduled to depart Frankfurt for Singapore on Wednesday night (Nov 23, Frankfurt time) has been pushed back to the next day after its pilots' union called for a strike on all continental and intercontinental routes. Passengers travelling within Germany on cancelled flights can use Deutsche Bahn trains, with tickets converted to rail tickets.
Other Lufthansa group airlines - Lufthansa CityLine, Germanwings, Eurowings, Air Dolomiti, Austrian Airlines, SWISS and Brussels Airlines - are not affected.
In July, it brought an end to the long-running industrial dispute with cabin crew through a deal on pay and working conditions, including a no-strike agreement and job guarantees until 2021.
Intending passengers are being advised to check the Lufthansa website.
The VC want a 3.7% pay increase backdated to 2012 while the airline offered 2.5% covering the next six years to 2019. "It is incomprehensible why the union is seeking the highest salary increase for the best paid group of employees", said Bettina Volkens, Lufthansa's human resources chief.