The actor, who rose to fame on "House", won for his work on AMC's "The Night Manager". His co-stars Tom Hiddleston and Olivia Colman also took home trophies from the annual awards ceremony, which is organised by the Hollywood Foreign Press Association.
Meanwhile The Crown - which follows the life of Queen Elizabeth II from her wedding day onwards - was named best drama series, with its star Claire Foy also picking up the prize for best drama actress. "And they wanted to say hello because during the shelling the previous month, they had binge-watched 'The Night Manager'".
There are a few things a memorable Golden Globes acceptance speech needs. The six-part thriller was adapted from the 1993 John Le Carre novel of the same name and made by the BBC and United States network AMC.
The arms dealer was played by Hugh Laurie, who won best supporting actor in a series, mini-series or TV movie.
"Thank you to also the many, many people who gave me this wonderful, extraordinary, once in a lifetime opportunity", said the actor. At the top of the list, a Donald Trump burn.
He started by thanking the Hollywood Foreign Press Association for the award, calling it an fantastic honor, then said, "I suppose more awesome for the fact that I'll be able to say I won this at the last ever Golden Globes". "It's just that it has "Hollywood", "foreign" and "press" in the title".
Hugh's award was one of three taken by The Night Manager, in what proved to be a triumphant night for British talent.