It was the earliest exit for a men's top seed at the Australian Open since Lleyton Hewitt at the same stage in 2003 and leaves the tournament without the top two seeds already following six-time champion Novak Djokovic's similarly unexpected reverse to Denis Istomin in the second round.
"I have to play very very well, that's the only way, no?", Nadal said of his upcoming match against Raonic.
Andy Murray reacts during a press meeting after losing his Men's Singles fourth round match against Mischa Zverev of Germany at the Australian Open Grand Slam tennis tournament in Melbourne on Sunday.
Murray had reached the quarterfinals or better on his previous seven trips to Melbourne Park - losing the finals in 2010 to Federer and in '11, '13, '15 and '16 to Djokovic. It means the world to me, and to have my whole family here, it's just awesome.
Where Murray descended into mutter mode in his match, Zverev, with nothing to lose, played with a smile on his face to win 7-5, 5-7, 6-2, 6-4.
It was his 200th career win over a top 10 player. Is tough. He's an opponent that make you feel that you're playing with a lot of pressure all the time because his serve is huge and he's playing very aggressive from the baseline.
Maria Francisca Perello, who has been dating Nadal since 2005, was present in the stands during his boyfriend's hard fought victory and the 14-times Grand Slam victor made it a point to mention her in the post-match interview. I've come back from them.
A three-time Grand Slam champion, Murray has reached the Australian Open final five times - he lost to Roger Federer in 2010, and Novak Djokovic in 2011, 2013, 2015 and 2016.
What will worry Nadal is the amount of balls that will be returned by Monfils, who has a habit of making shots many players on tour would get nowhere near.
"You know", he said with a smile. "There were a few points where I didn't know how I pulled it off but somehow I made it", Zverev added.
The 29-year-old served up his first ace to take the first set and Murray was forced to up his level of aggression to bring the match back to parity with a backhand victor down-the-line on his fifth set point in the second.
However, the Spaniard has begun the new year on a positive note, highlighted by a hard-fought five-set victory over German rising star Alexander Zverev in the third round.
Murray was agitated right from the start, hitting into the net early on and screaming loudly as glanced at his players' box. I was full of confidence coming into the beginning of this year. I mean, still, even had I got through this match, Nishikori or Roger are waiting.
"For sure it's different, I'm not saying that it's not, but (at) the same time, we saw that everyone can beat everyone", Dimitrov said.
But it was the manner in which Zverev took the attack to Murray, and the unbelievable quality with which he did it, which left the Scot constantly on the back foot and took him out of his comfort zone.