Venus Williams is on track to win her eighth Grand Slam title.
She has a booming serve and phenomenal groundstrokes, with a game suited to the fast and hard courts of the Australian Open.
CoCo Vandeweghe advanced to her first major semifinal, anywhere, beating Grand Slam winners in back-to-back rounds.
Williams' coach, Patrick Mouratoglou, picked Konta earlier in the week as a leading threat to his player, and the theory will now be tested when they meet for the first time.
Facing Ukraine's Elina Svitolina in the third round, she dropped her only set of the tournament thus far against the 11th seed but prevailed for her first round of 16 appearance in Melbourne.
He advanced to the final eight in Melbourne for the third straight year with a 7-6 (6), 3-6, 6-4, 6-1 win over No. 13 Roberto Bautista Agut.
Juergen, the older of Austria's Melzer brothers, called his straight set win over brother Gerald in Wimbledon qualifying two years ago "the worst tennis day" of his life.
"An unbelievable fight, " Makarova said of her first win over sixth-seeded Cibulkova, the 2014 finalist at Melbourne Park.
Konta smiled: "When they announced I'd be playing Serena, everyone went: 'Ooooh!'" But I'm still here. But to do it at this stage of a Grand Slam is kind of insane.
Konta, on a nine-match winning streak, is shaping as a genuine title contender after she demolished Makarova. That meant the No. 3, No. 4 and No. 6 seeds on the women's side were all gone by the fourth round.
The 36-year-old Williams beat Anastasia Pavlyuchenkova 6-4, 7-6 (3) on Tuesday, becoming the oldest player to reach the semifinals at Melbourne Park in the Open era.
It is the first time Venus has advanced to the quarter-finals of a grand slam without losing a set since 2010.
"Now I have played her, I know what to expect".
Brady also got past Heather Watson in an epic second round match, where the Brit failed to convert a number of match points, but surprisingly eased past Elena Vesnina on Saturday.
Having won their prior encounter in Sydney last week, Pavlyuchenkova backed it up with another stellar performance to see off Kuznetsova 6-3, 6-3 and books her place in her first Australian Open quarterfinal, completing the feat of reaching the quarterfinals of all four Grand Slams in the process. Do you think how far have you come or how far she's come? "She's super fit. She has a good game". We did a very good off-season, so there's no reason why she should have any physical problems here.
She paid dearly against a veteran who is still a unsafe force, making the fourth round or better at three of the four grand slams previous year.
In the opening match tomorrow, Serena Williams is the [1.21] favourite to get past Barbora Strycova, and if there is going to be a vulnerable front-runner tomorrow, it will be the Czech.
The 35-year-old had previously not defeated Strycova in three matches at the majors.
"Where there's a will, there's a way", she told the press (via ESPN) after dropping to Karolina Pliskova at the U.S. Open previous year.
Well, reality was stranger than fiction at Rod Laver Arena, as the 25-year-old Californian stunned the reigning French Open champion and No. 7 seed here.