But Zinedine Zidane's side face a bigger struggle to retain their Champions League title, after being handed a tough quarter-final draw against Bayern Munich.
Ancelotti only recently steered Real Madrid to one of the three Champions League titles he has to his name as a coach.
"It is going to be exciting to play against them".
"Dortmund and Monaco meet in UEFA competition for the first time", Champions League said in a tweet.
"They are one of the most famous teams in the world and we only have to focus on the present knowing that we are a very strong team and that we can compete".
"It will be master against pupil for sure", Zidane said on Friday. Besides Madrid, he also coached AC Milan to two Champions League titles.
The final tie in Europe's premier club competition pits Manchester City's slayers Monaco against Borussia Dortmund.
"Facing a team who have reached the final in two of the last three seasons is a massive challenge".
The new A380 plane features stars Cristiano Ronaldo, Gareth Bale, Sergio Ramos, Marcelo and Karim Benzema painted on the side.
"Wow! It'll be a great quarter-final between two clubs with great history", he said.
The league will host intense quarter-final clashes, assured the Friday draw at Nyon, Switzerland.
"For me, of course this is a special game".
"It'll be a hard game but we're confident and we have a chance to go through".
"But first we have a home game and we want to continue our good run at home and get a good result". We know what a strong side Barcelona are, but we must be courageous and take the game to them.
Anderlecht and United last met in the group stage of the Champions League in the 2000/01 season, with United losing 2-1 in Belgium, future Everton and Fulham striker Tomasz Radzinski scoring both goal.
They were the last team to win a European match in Munich when Pep Guardiola's Bayern was thrashed 4-0 in the 2014 semi-finals - with Ancelotti in charge of Real - as Sergio Ramos and Ronaldo scored twice.