And on Wednesday's second-leg round-of-16 tie against City, Monaco overturned a 5-3 deficit to win on away goals after a 6-6 aggregate draw.
With just three wins from last nine Premier League games, Liverpool have seen their title bid fade but back-to-back victories over Arsenal and Burnley have helped strengthen their grip on a top-four spot.
Yet Guardiola received positive communication from Mubarak.
City are [2.04] favourites to rebound from their European disappointment while Liverpool are [3.95] to do the Premier League double over the Citizens for the second season running.
"If he can be involved in team training on Saturday then physical-wise he has no issues because it's good for him".
"Always we are going to take a decision but I always feel that support in the good moments and bad moments, especially in the bad moments".
FA Cup semi-finalists City lie third in the Premier League - a point and a place above a Liverpool side who have won the past four top-flight meetings between the two.
"There nearly seemed no belief in that semi-final". "I have more power than ever in my life as a manager", he said. "I thought it makes sense to see it as a real opportunity and not put some special pressure in it".
It is clear improvements at the back are needed, and with money no object to City, just who could they sign?
Guardiola said: "All the managers and sporting directors want to improve and get better".
Monaco go through to Fridays draw for the last eight in Nyon carrying French hopes following Paris Saint-Germains shock elimination, while Guardiola suffered his earliest Champions League exit as a manager. I met Sheikh Mansour in Abu Dhabi and I know the plan.
"We all have to get used to it a little bit". "The way he's working, the way his team is playing makes me want to study the games".
Liverpool have beaten City five times in the last six PL meetings so getting almost 3/1 looks a great bet here.
"There is a reason why he didn't play because he was injured", he added.
"We work really hard on it all week to bring this on the pitch but I'm sure he does the same".
"That is what I have said many times".
But the Belgium global has been fit and available for selection for the past two weeks and his continued absence from Guardiola's plans has raised eyebrows among senior figures and within the squad.
"We forgot to fight as a team, defend as a team and press as a team".
Yaya Touré's agent, Dimitri Seluk, has said he has held talks over a possible move for the midfielder, whose contract at City expires this summer.
"We had a lot of specialists to try and find it out and it looks like we found a solution now and he does not have these problems any more".