A potential season-ending knee problem to Sadio Mane is just the latest in a long list of injuries which has shorn Klopp's side of first-choice players.
Earlier this week, Liverpool striker Divock Origi declared himself ready to fill the gap left by forwards Lallana and Mané - having come from the bench in place of the Senegal winger to score the third goal in their 3-1 victory over Everton.
Despite results of a first scan on the forward's knee coming back inconclusive due to swelling, Klopp ruled the Senegal global out of contention for Wednesday night's meeting with Bournemouth, admitting the situation was not "very positive".
The extent of the 24-year-old's injury is still inconclusive due to swelling, but according to The Times, Mane may still need an operation that would end his season. It's swollen because of different reasons.
"But even though that is possible, the more hard the situation, the better it feels when you deal with it".
"I like his desire but I thought in this game it makes sense that when you've already lost one offensive player, you save another one a little bit".
"The only thing that I can say for sure is that we will not be available tomorrow".
"We spoke a lot about the national team and said it's not so cool that they had to leave wherever to go wherever, but obviously I have to say thank you to the whole staff of the Brazil national team because they gave us both boys back in a fantastic mood", said manager Jurgen Klopp.
"It is not very positive". But we can not say what it is exactly.
The striker, who last appeared for Liverpool in February, has recovered from a hip strain and could be part of Liverpool's matchday squad on Wednesday. "It's possible [his season could be over] but why should I say that now?"
With Sadio Mane definitely out of tomorrow's game, moving Milner onto the right wing makes ideal sense, but if that happens, who will replace him at left-back. "We have to see".
The Senegal worldwide scored the opening goal against Everton, as Klopp's team extended their unbeaten run to four matches. "A few other clubs had this", he said.
"We will show that we learned from this year", Klopp added. "The squad will change in a few positions, we will still have young players in the squad".
Liverpool face a tricky test at Anfield as they square up against Bournemouth.
"As a manager, I can't really remember the last time I had all players available and decisions to make were so hard that I thought "oh my God, I'm leaving five players at home and really good players on the bench" because that's really rare", said Klopp.
"We want the same, we expect results from ourselves and we want to fight for everything".