Last year's National Basketball Association champions now lead 2-0 in their Eastern Conference semi-final in the best-of-seven series.
Wednesday's loss was Toronto's fifth straight post-season rout in Cleveland.
Quotes Toronto Raptors head coach Dwane Casey looks on from the sidelines.
On Monday night, James jokingly swiped a beer bottle from a surprised courtside server during the third quarter of Cleveland's playoff game against the Toronto Raptors and considered sipping it before handing it back.
The team said Lowry will undergo tests later today.
If the Raptors are unable to make this much of a series, the existential questions will be right back in front, again.
"We won our first two games here previous year, then went up there and got our butts kicked", head coach Ty Lue said before Game 2.
James went 4-for-6 from three in Game 2, the second time he has hit two-thirds of his attempts on at least four attempts in these playoffs (6-for-12 in Game 3 against Indiana). Cleveland is 9-0 since losing Game 4 of last year's NBA Finals. They had open looks all over the court in the opening minutes of Game 2, and couldn't convert them.
Toronto Raptors point guard Kyle Lowry sat out Thursday's practice with a sprained left ankle and is questionable to play in Friday's Game 3 of the Eastern Conference second-round series, the team announced. He left briefly, then returned for eight minutes before being removed for the rest of the game, having scored 20 points.
James entered Wednesday night's Game 2 of the Eastern Conference semifinals between Cleveland and Toronto needing 25 points to surpass the inimitable Abdul-Jabbar (5,762 points).
"I'm just feeling pretty good. We know (DeRozan) is a great player and we don't want him to get comfortable".
James jumped to No. 2 on the all-time playoff scoring list, passing Kareem Abdul-Jabbar. James (5,777 points) now only trails Michael Jordan (5,987), the player to whom he has been compared since he was a teenager, for the most points in postseason history.
"Winning championships in the '80s and things of that nature and how many points he's put up". "He's somebody you read about". The Raptors' last win on the road in Game 2 of a playoff series was April 26, 2001, at NY during a first-round series. Whether that can mean wins is another question - maybe they should get a lead in a game before we start going down that road. Before the series began it was believed that this Raptors team was better than last years squad, however it doesn't feel so anymore. "We take our butt whooping and go home".
"They're getting so many open threes, credit that they move the ball well, but our rotations have to be better and our communication needs to be way better".
The one (and maybe the only) thing the Raptors have going for them is that this is not unfamiliar territory.
Casey, though, is confident his team can go home like it did previous year and even the series.
"I addressed it in the locker room after the game", coach Tyronn Lue said. "I believe in our guys. It's on us to be able to take out all the other key players and not let them get going". "I've seen it before".
Cleveland's defensive game plan to double-team and trap DeRozan has worked to a charm.
"Yes, that would have been helpful", DeRozan said. To lose like we did and play like I did sucks.
"I don't know, man", said James, who is 19-0 when leading a series 2-0.