The flyby of the Juno spacecraft, surveilling the 10,000-mile-wide (16,000-kilometer-wide) storm, is scheduled for 9:55 pm Monday (0155 GMT Tuesday). It's huge, larger than Earth in diameter. "No scientists really understand exactly how that storm is created or why it could last so long".
Juno is equipped with instruments created to peer through the cloud layers and gather data on the inner workings of Jupiter's atmosphere. Essentially, the Spot is an vast high-pressure system, slowly swirling in relatively the same position in Jupiter's atmosphere, trapped in place by the jet streams to the north and south of it.
"It's possible that the roots are quite deep", says Bolton. "Until now, we've basically relied on images of the cloud tops".
NPR reports that Bolton and his colleagues will be watching the fly-by closely with their astronomical tools to take measurements of the planet around the time Juno arrives, so they can have as complete of a picture of the storm.
"The success of science collection at Jupiter is a testament to the dedication, creativity and technical abilities of the NASA-Juno team", said Rick Nybakken, project manager for Juno from NASA's Jet Propulsion Laboratory in Pasadena, California.
Another Juno instrument can measure the gravity field around the spot. Keep an eye on NASA's website over the next few days to see the raw images coming in.
"Maybe there's a blob going around Jupiter that's underneath the Red Spot, and we may be able to see that", he says.
Juno will fly within 5,600 miles of the storm's surface - offering the closest-ever view of this massive weather system. Each future flyby of the Red Spot will focus on a different kind of science.
NASA estimates that eleven minutes and 33 seconds later, the spacecraft will have moved another 24,713 miles (39,771 kilometers) and will be precisely above the cloud tops of Jupiter's Great Red Spot. Bolton is confident that the images will not disappoint.
"Jupiter is stunning when you get near it", he says.