According to NASA, the Great Red Spot's winds peak at approximately 400 miles per hour and have been swirling for more than 150 years.
Juno is making its closest path near Jupiter's red spot and photos have been released from the journey.
The Great Red Spot is a massive spinning storm that has always been a focus of fascination for researchers as well as space enthusiasts. The spacecraft passed about 5,600 miles (9,000 kilometers) above the clouds of this iconic feature.
"Now we have the best pictures ever of this iconic storm". In more recent times, it has appeared to be shrinking.
NASA's Juno spacecraft has been orbiting Jupiter since July 2016, orbiting the massive planet five times so far, and collecting a lot of valuable data in the process.
Jupiter's Great Red Spot captured by NASA's Juno mission, enhanced in color for a detailed view. It is completing its sixth orbit of the planet, the solar-powered craft will fly around six more times before steering itself to certain, planned death. Juno's next close flyby of Jupiter will occur on September 1.
"For hundreds of years scientists have been observing, wondering and theorizing about Jupiter's Great Red Spot", said Scott Bolton, Juno principal investigator from the Southwest Research Institute in San Antonio.
Juno launched on August 5, 2011, from Cape Canaveral, Florida.
The JunoCam instrument was added to the probe primarily for public-outreach purposes, scientists with the mission have said.
Jim Green, NASA's director of planetary science, described the highly-anticipated images as the "perfect storm" of art and science.