"Like many of you here tonight, I remember visiting the Natural History Museum as a child, and being inspired with a love of nature", she said.
The revamp focuses on the "authenticity" of the museum's collection, and sees Dippy the Diplodocus cast swapped out for a 25-metre blue whale skeleton called Hope, which is suspended from the ceiling as the focal point of the entrance area.
Hope came to the museum shortly after it opened in 1881.
The blue whale will reflect the story of evolution, current diversity and increasingly crucially, our role in the planet's future.
As the largest-known animal to have ever lived on Earth, Hope's position in the main hall is meant to serve as a potent reminder of environmental destruction.
Despite being known for her impeccable style and having one of the world's most envied wardrobes, it wouldn't be unfair to note that the Duchess of Cambridge's aesthetic is often a little safe.
The 126-year-old skeleton has been unveiled today (Thursday) as its predecessor "Dippy" prepares to head out on a United Kingdom tour.
"Hope is the only blue whale skeleton in the world to be hung in the diving lunge feeding position".
Hintze Hall will reopen to the public on Friday following six months of refurbishment.
The producers of the programme spent over two years behind the scenes at the Natural History Museum following the people involved in what has been one of the most unique engineering challenges ever undertaken. The Natural History Museum also hopes to redevelop its outdoor space and expand digitisation. In 2014, a British-Australian billionaire businessman and philanthropist - Sir Michael Hintze (above) - donated £5 million to the Natural History Museum.