The event was attended by many high-profile artists including Mary J. Blige, Kelly Clarkson, Ciara, and Camila Cabello who were moved as Miss Gomez brought up her best friend "sister" and kidney donor Francia Raisa, on stage.
"Honestly, I couldn't be more grateful for the position I've been given in my career from 7 to 14 to now", she continued.
"I like to choose to live my life in a way where I want to be weight-free, and I know that's impossible to do because I have a million [eyes] on me right now", she explained.
Francia, who we've already dubbed the world's best BFF, also had kind words to say about SG.
"To be honest, I'm not sure how to answer - not because I'm trying to back away from it", she said in an interview with Billboard magazine. "We are so close that we literally are the same kidney type".
"I mean I don't think anybody truly, actually cares".
"When I found out I was a [kidney type] match for Selena, I didn't think twice about it", Raisa said before she handed Gomez the award.
Over the summer, when Gomez was still dating The Weeknd, she revealed that she underwent life-saving surgery. She went on to thank her team for helping her through a rough year.
"When people look up to me, I want them to see my life and have it reflect theirs and understand that if I can make it through everything that I've made it through and still making it through, you can do it as well". I feel incredibly lucky'. "And I got to do a lot this year, even though I had a couple of other things to do", Gomez told the crowd at the Hollywood gala. It's a really attractive thing and I have to remind myself of that.
Selena's title has previously been picked up by Taylor Swift, as well as fellow musicians including, Beyonce, Pink and Fergie.