The researchers determined that young men given ibuprofen developed compensated hypogonadism, a condition that occurs when males have normal levels of testosterone, but higher levels of luteinizing hormone (LH), a substance that stimulates the production of testosterone.
Erma Z. Drobnis, a University of Missouri, Columbia, professor who specializes in fertility, says this study is important, given how common ibuprofen is, even with such a small sample size. The men were then divided into two groups, 14 in an ibuprofen group and 17 in a placebo group.
Within just two weeks, it seems that the testosterone-producing hormones in the subjects became linked to the amount of ibuprofen in their blood.
The study involved 31 men, ages 18 to 35.
However, despite the change in LH levels, the men's testosterone levels didn't change. Before he stepped down in November 2016 he asked players about their use of over-the-counter painkillers and found that almost half of those who played in the past three World Cups took anti-inflammatory drugs, such as ibuprofen, every day.
Men who take high doses of ibuprofen for long periods of time may reduce their fertility, according to a new study from Denmark.
For short-term ibuprofen use the effects of compensated hypogonadism are reversible, however the researchers state how it is unknown whether these effects are reversible for long-term ibuprofen use.
However, because the study is small, more research is needed to confirm the results.
Bernard Jégou, a senior author on the study at the French National Institute of Health and Medical Research, said he saw no problem in people taking ibuprofen to alleviate pain in the short term - for toothache, for example - but warned against taking the drug for months on end if it was not strictly necessary.
The new study is a continuation of research that first began with pregnant women, Jégou told CNN, in which the researchers examined the health effects when a mother-to-be took one of three mild pain relievers found in medicine chests around the globe: aspirin, acetaminophen (also known as paracetamol and sold under the brand name Tylenol) and ibuprofen.