As a member of the Dolphins earlier this year, Ajayi became the first London-born skill player to take the field for a regular-season game in his home city.
English Premier League club Tottenham Hotspur's new stadium will serve as the site for an NFL game for the first time ever in October, joining Wembley Stadium and Twickenham Stadium, as United Kingdom venues that have hosted American football. The Titans and Chargers will face off on whichever date the Eagles and Jags don't play.
The 49ers haven't played overseas since they played the Jaguars in Wembley in October 2013, when they thrashed Jacksonville, 42-10, in their most lopsided victory of that season.
Kickoff time has not been announced.
The NFL revealed it's matchups for 2018 live via London on Periscope.
The Jaguars have committed to play at least one game in London every season until 2020.
This will be the Chargers' sixth game played overseas in franchise history and second to occur in the regular season.
The Raiders, Jaguars and the Chargers are the designated home teams for each matchup.
Normally, it'd be unfortunate for a team to lose one of its home games, especially when one has to travel extremely far to play the game.
The Jaguars are no strangers to London, owning a 3-2 record since first appearing in the International Series in 2013.
The date of the game will be announced when the National Football League announces their 2018 schedule, but for now, the game is scheduled to be held on either October 21 or October 28. Three games will be played at the venue in a future year to make up for it.
The Seahawks announced that ticket information will be announced by NFL UK on January 18.
The Raiders playing a 2018 game in London was a terribly kept secret, one NBC Sports Bay Area's Greg Papa discussed months ago on The Happy Hour. Fans can sign up at www.chargers.com/london for the latest information on the Chargers' trip to London.