The Turkish Foreign Minister Mevlut Cavusoglu also called out Russian Federation and Iran to stick to the joint accord they signed with Turkey previous year agreeing on a "de-escalation zone" in Idlib which were set up to scale back the conflict.
He said that Washington should understand that PYD and YPG do not represent all ethnic Kurds of Syria.
Turkey and the United States have been at loggerheads over Washington's policy of support for the YPG, which Ankara views as an extension of the Kurdistan Workers Party (PKK) that has waged an insurgency in Turkey's largely Kurdish southeast for more than three decades.
During the September round of Astana talks, Russia, Iran and Turkey, the three states that serve as guarantors of the Syrian ceasefire, agreed on all four de-escalation zones in Syria - one in Idlib including parts of neighboring Hama province, the second one in the north of the central province of Homs, the third one in eastern Ghouta near Damascus and the third one in the country's southern province of Deraa.
Violence in Idlib region has recently escalated, with Syrian government forces, supported by Russian Federation, trying to regain control of the rebel-held area.
"Russia and Iran must stop the Syrian regime".
It conveyed "uneasiness" to the Russian ambassador Tuesday, calling the strikes a "violation of the borders of the Idlib de-escalation zone" established by Turkey, Iran and Russia, according sources at the foreign ministry.
Furthermore, the offensive could lead to collapse of Astana process and eventually the hardly established cease-fire in de-escalation zones. The Russian embassy in Ankara did not issue any comments.
Idlib province is nearly entirely controlled by anti-government forces that are dominated by a jihadist outfit known as Hayat Tahrir al-Sham (HTS) consisting mostly of former fighters from the Al-Nusra Front, an Al Qaeda affiliate.
"Firstly, these are provocations aimed at the collapse of the earlier reached agreements".
"Russia and Assad try to find excuses to clear Idlib from rebels, even makes ones up if necessary".
Turkish President Recep Tayyip Erdogan told Russian counterpart Vladimir Putin on Thursday he should stop Syrian attacks on its opposition in northern Syria if he wants peace negotiations to succeed, Turkish presidential sources said.