Her worst defeat, however, came in the French Open final against Jelena Ostapenko - she failed to close out a final she had led by a set and 3-0 and finally lost in three sets giving the Latvian the chance to win at Roland Garros as an unseeded player.
"I'm waiting for the bananas", she told chair umpire Fergus Murphy when asked what she was doing.
Coco Vandeweghe, in her 6-7, 2-6 loss to Timea Babos, received a code violation from the chair umpire for delaying the start of the second set by "waiting for the bananas".
Stephens' poor run since winning at Flushing Meadows in September continued, with the 13th seed crashing out to Chinese number two Zhang Shuai, who made the last eight two years ago.
It only delayed the inevitable, though, and normality was quickly resumed as Nadal closed out the match in an hour and 34 minutes. "I always get huge support in Australia", said Nadal.
"Obviously I wanted to start with the right intensity, which I have", Djokovic said.
She was 4-1 down in the second before knuckling down to race home and a second round clash with China's Duan Yingying.
"Obviously I know I'm hitting the ball well", Kyrgios said. "She's very experienced player and she's very long time on tour", said the Latvian. That's all really. I really focus on this.' What keeps him motivated?
Nadal will next face Leonardo Mayer on Wednesday after the Argentine overcame Chilean Nicolas Jarry 6-2 7-6 (7-1) 6-3.
After an injury-plagued 2016, Nadal rose to the top of the tennis world in 2017 with a sensational year that included victories at Roland Garros, the US Open, Monte-Carlo Masters, Madrid Masters, Beijing Open and Barcelona Open. But now, whether Federer agrees with it or not, he is back in his usual favourite status, arriving at Melbourne Park as the second seed for 2018's first Grand Slam. Bill Babcock, the director of the Grand Slam Board, stressed that the rule was still in a trial period and would be evaluated when a full year of data was available after the United States Open. It's a new situation for me. "The real victor from this is the tennis fan who gets to see high-quality, competitive tennis, and I think the players are embracing it".
The world number one is bidding for a second Australian Open title after losing last year's final to Roger Federer and was never in any trouble against the world number 79 from the Dominican Republic.
Simona Halep will sport her "lucky" red dress and Caroline Wozniacki says she is playing better than ever as both aim for a first Grand Slam victory when the Australian Open starts on Monday.