The four-time major champion fired eight birdies in a superb display at Bay Hill on his way to a bogey-free 64, seeing him finish three strokes clear of nearest challenger Bryson DeChambeau.
Northern Ireland's Rory McIlroy is two shots off the lead after a five-under-par 67 in the third round of the Arnold Palmer Invitational in Florida. I'm really proud of myself and so happy to at last get the win.
Golf fans get a kick out of heckling pro golfers for the same reason people get really excited when a celebrity falls for a "BOFA" joke on Twitter - because suddenly, a member of the anonymous crowd has managed to make a person with structural power look like a fool.
McIlroy had not won since the day Palmer died in 2016 but snapped his skid on the course where Palmer used to greet winners as they exited the 18th green.
Woods, whose last tournament victory came in the 2013 Bridgestone Invitational, told Sky Sports: "I've gotten the feel of playing tournament rounds".
"They want to try and replicate that, which is great - it's great for the tournament, it's great for us - but golf is different than a football game, and there's etiquette involved, and you don't want people to be put off from bringing their kids when people are shouting stuff out", he said.
"I didn't feel like I got a lot of ideal numbers".
He made a 15-foot birdie putt on the 13th to take the lead over hard-luck Henrik Stenson, and then rolled one in from 20 feet on the next hole.
"I wish I walked up that hill and got a handshake from him, " McIlroy said. Stenson missed a short birdie putt and a 12-foot eagle attempt on the back nine Saturday.
'I knew I was close. I thought I really putted well this week.
Woods, wearing his trademark red shirt and black trousers, managed his 10th consecutive PGA par-or-better round, his longest such streak in six years.
Woods shared 10th place on the course where he has captured eight career titles.
Tiger Woods got within one of the lead on the back nine, but he fell back with bogeys on 16 and 17 and finished 10 under.
"I didn't decide what I was going to do", Woods said.
Hopefully, The Arnie will never turn into the Phoenix Open, where fans are allowed to be loud and annoying - especially at the par-three 16th hole, which is surrounded by hospitality tents filled with drunken fans. I didn't commit to it, bailed out on it.
DeChambeau briefly moved back alongside Stenson with a birdie at the 14th but bogeyed the next, allowing the Swede to temporarily double his lead with a two-putt gain at the par-five 16th.