Lomachenko (11-1) became the fastest ever to win world titles in three weight divisions with his victory at Madison Square Garden in NY.
Despite being sent to the canvas in round six of his lightweight debut, Lomachenko recovered and earned the stoppage after Linares was unable to recover from a powerful flurry of body punches in the 10th.
Linares managed to get back up to his feet but referee Ricky Gonzalez waved off the contest at the 2:08 mark.
Twitter went wild over Lomachenko staking his place in boxing history. Although Lomachenko has the higher "KO' ratio, he's not actually physically knocked as many opponents out as Linares, but has instead made them quit through frustration". Linares though was accurate with his counter punches in the first and landed a good lead left hook at the end of the round.
Despite blood dripping into his eye, Linares put up some dogged resistance before Lomachenko wrapped up the victory with a superbly timed left hook to the Venezuelan's liver.
The reach and weight disadvantage definitely gave Linares more or a chance than the usual Lomachenko opponents.
The official time of the stoppage was 1:04 of the first round of a scheduled eight round bout. Linares, the bigger fighter, seemed to be in control of the second round, though he had to take note of Lomachenko's speed and footwork.
Lomachenko's last fight was also in the Garden, and when his work was done with his fists he basically shrugged his shoulders. Lomachenko got up easily and didn't appear hurt, but Linares carried the confidence from the knockdown into a strong seventh round. Even with the odds are against him for the first time in his career, Linares is putting on a confident front when he says "When I win this fight, everything in my life, everything in my career, is different". Oh, just 12 fights, 11 wins and three world championships into his pro career, he's already verging on superstardom and may well be boxing's greatest pound-for-pound fighter.
Lomachenko resumed his two-fisted attack and continued to pepper Linares with his lightning quick fists.
Lomachenko, a two-time Olympic gold medalist, still holds the WBO super featherweight title.
"The fight was getting interesting", Linares said.
Lomachenko moved up to 135 pounds to challenge Linares because he couldn't secure title unification fights at 130 pounds.