The Group A encounter featured few good chances for either side before a late surge from Uruguay culminated in Gimenez's 89th-minute victor.
To make matters harder, Russian Federation will be confident after their crushing 5-0 victory over a hapless Saudi Arabia team, who Uruguay will surely beat to all but seal their place in the last 16 with a game to spare.
Jose Gimenez was the unlikely 89th-minute match victor as Uruguay defeated an Egypt side shorn of star man Mohamed Salah 1-0 in their World Cup opener on Friday.
The 26-year-old set the Premier League alight last season by scoring 32 goals in 36 appearances - one more than Suarez's scintillating last campaign for the Reds in 2013-2014.
At the other end, Uruguay strikers Luis Suarez and Edinson Cavani missed their chances.
Mohamed Salah has not been named in Egypt's starting XI as they begin their World Cup campaign against Uruguay. "Yesterday we were quite certain during that training session he would play".
"He (Ramos) is a bloody animal, he denied Salah a place in the team today, he denied him the Uefa Champions League final glory he deserved... he has denied us (Egypt) the win".
The double-stacked cake with candles was taken to a hotel where the Egyptian team is staying for the World Cup.
He put the decision made by current Egyptian manager Héctor Cúper, in which chose not to risk Salah any earlier than necessary, in context.
Cavani and Suarez didn't receive the support they needed and at times dropped back to midfield as playmakers, not a role for a duo that has combined for 93 global goals.
Uruguay face the Saudis next Wednesday and Russian Federation on June 25 in their final Group A game.
Egypt's final game is against Saudi Arabia.
The north Africans, contesting their first World Cup since 1990, were for the main part fairly comfortable in defence and Arsenal's Mohamed Elneny was a constant presence at the base of Egypt's midfield. "In the history of football we have broken a spell (winning the opening game)", he added.
"During this period, all the players observed Ramadan", Cuper said.