Germany had been shambolic in preparation towards the World Cup. Not only are the Germans the defending the World Cup champions, they are also ranked No. 1 in the Federation Internationale de Football Association rankings. Osorio is nicknamed the "Professor" and his planning famously extends to copious notes and ring-binders, but delve even deeper into his remarkable journey to football's greatest stage and the suspicion only grows that there will be no more meticulously prepared team in Russian Federation.
Germany hit back, Toni Kroos rattling the crossbar with a 25-yard free-kick that needed the fingertips of a scrambling Ochoa to keep it out, but Mexico barely clung on to their advantage.
Germany have averaged 3.5 goals per match in their opening games of the World Cup since they last lost an opener - 36 years ago against Algeria.
However, their attempt to create history got off the worst possible start as they feel to a shock opening game defeat to Mexico.
Green-clad fans, many with oversized sombreros as big as their hopes, filled the streets outside St. Basil's Cathedral, packed the Metro and made the long walk into Luzhniki Stadium.
Lozano, a 22-year-old forward from the Dutch league nicknamed 'Chucky, ' got Mexico going with a deflected shot over the bar in the first minute.
"Our cover was often not good and we were left many times with just Jerome (Boateng) and myself in the back", said center back Hummels, one of several Germans who will not want to watch a replay of Hirving Lozano's 35th-minute goal.
Timo Werner could have scored when he picked up a ball near the penalty spot, but his shot went straight to Ochoa.
Mexico pulled back into a more defensive formation midway through the second half as players exhausted and Germany attacked. The four-time world champion was expected to be a solid contender for its fifth overall victory, but couldn't find a path to the win against the stalwart Mexican defense.
Mexico's top global scorer, Javier Hernandez, may not be an automatic starter these days but his speed will come in handy for Juan Carlos Osorio's team.
Kimmich's charging runs far up the field can be a blessing and a curse for Germany.
Germany who hadn't lost an opening game at the World Cup since 1982 became the 5th defending champions to be humbled in their first World Cup game.
"We were not effective in the spaces". Hirving Lozano's stellar strike sealed the deal for the Latin Americans who fought bravely against a star-studded German line-up to clinch an important victory and three points to take the top spot in the group.