"The partner with whom Europe built the post-World War order appears to be turning its back on this shared history", the French president said.
Britain will also be in line for a "strategic partnership" after its departure from the European Union scheduled next year - but Macron warned that Brexit must not come at the cost of the unity of the rest of the EU.
"I don't want to give the illusion that my position within the government suggested that we are answering these problems properly, so I'm leaving the government", he said.
"But on a challenge this serious, I find myself resigned to it every day, adapting to it a little more each day, even though the global situation with a planet that's becoming a sauna requires us to change our scale, change our scope, change our thinking", Hulot said.
French President Emmanuel Macron is calling on the European Union to boost military cooperation and stop relying on the United States for defense while reaching out to Russian Federation to develop a "strategic partnership".
Nicolas Hulot said on air with French news channel BFM TV that he is disappointed with the government's track record on issues such as pesticides, biodiversity and climate change, CNN reported. The move deals a stinging blow to the environmental credibility of President Emmanuel Macron.
Hulot is a former television presenter and green activist who enjoys a popular following with the younger generation of French voters, many of whom grew up watching his nature program on television in the 1990s.
Shortly after the US announced its withdrawal from the Paris accord, a global pact to combat climate change, French President Emmanuel Macron assumed the mantle of environmental crusader with a pointed rebuke of the Trump administration: "Make our planet great again", he declared just hours later.
Benjamin Griveaux, spokesman for the French government, told BFMTV he regretted Hulot's decision.
"He didn't win all his battles but that's the way it goes for ministers", Griveaux added.
Macron said "it's up to us" to guarantee Europe's security and therefore its sovereignty.
He also explained that he felt alone against the agriculture minister, Stephane Travert, who is considered to be a defender of intensive farming and glyphosate, a weedkiller.
"There is still no energy transition policy in France", Julliard said.
His doubts about remaining in government had grown over the summer as devastating droughts were met with a tepid political response, he said.
Rasmussen said he believed that there would be a division of labour between North Atlantic Treaty Organisation and Europe in the future, and said Denmark should begin to debate its European Union defence opt-out.