The blistering op-ed in the New York Times branded Trump "amoral, petty and ineffective" and claimed there are "many" senior aides in the Trump administration working to curb his "worst inclinations".
President Trump called the letter-writer "GUTLESS", blasting the New York Times for publishing an anonymous op-ed.
It is, in other words, the type of story pretty much any editor would dream of having fall into his lap - which is essentially what happened to Times op-ed page editor Jim Dao, who was approached by the unnamed official through an intermediary several days ago.
Trump railed against the op-ed during a meeting of dozens of sheriffs from across the country on Wednesday, calling the anonymous piece "gutless".
In the forthcoming book being released next week, Woodward claims that Mattis told associates that Trump "acted like - and had the understanding of - a fifth- or sixth-grader". "So, well done, New York Times".
Mr Trump labelled the anonymous writer "gutless" and the newspaper as "phony".
"We have a president who's there, but he is not capable of doing the job or living up to the responsibilities". "This person works for the Trump administration".
Pompeo said if the piece is true, the Times should not have chosen to, "take a disgruntled, deceptive, bad actors' word for anything and put it in their newspaper".
Ben Sasse of Nebraska - a frequent critic of the president - said the views in the op-ed were "not surprising".
"So basically", Times investigative reporter Jodi Kantor observed in a tweet on Wednesday, "Times reporters now must try to unearth the identity of an author that our colleagues in Opinion have sworn to protect with anonymity?"
The writer also alleged "there were early whispers within the cabinet of invoking the 25th Amendment" because of the "instability" witnessed in the president.
Dana Perino, the former White House press secretary under George W. Bush, called the mysterious author of the op-ed "extremely self-indulgent".
"We are disappointed, but not surprised, that the paper chose to publish this pathetic, reckless, and selfish op-ed", Sanders said.
Anonymous officials who have been quoted in previous news reports have often been identified as "a senior White House official", which narrows the scope to people working specifically for the White House - instead of the broad number of agencies within the Trump administration, such as the Department of Education.
There have been previous reports by journalists and former White House staffers of upheaval in the White House West Wing since Trump's January 2017 inauguration.
Trump can be a handful, right, but the bottom line is that people around him are making him a successful president.
White House Press Secretary Sarah Sanders said "the coward" who wrote the piece should step forward and resign, saying "he is not putting country first, but putting himself and his ego ahead of the will of the American people". It's like there's a sign that says 'In case of emergency, break glass, ' but these guys are like, 'I mean we could break the glass, but then there'd be glass everywhere.