It will strike with torrential rains, powerful winds and potentially devastating flooding.
As Hurricane Florence strengthens in the Atlantic, the National Hurricane Center over night shifted its forecast south, raising the potential for tropic storm-force winds to parts of Florida as soon as Friday evening.
More than one million people have been ordered to evacuate along the North and SC coast as Hurricane Florence moves in.
A storm as big as Hurricane Florence will hit with a "one-two punch" deluge of water, Erik Salna, the associate director of the International Hurricane Research Center at Florida International University, says.
On Ocracoke Island along North Carolina's Outer Banks, Kelley Shinn and her partner packed their Jeep with clothes and other things and took a ferry to the mainland. "Disaster is at the doorstep and it's coming in".
Thousands of residents in North and SC have fled their homes as Hurricane Florence, the biggest of the extreme weather conditions on the map, looks set to tear its way through the eastern seaboard.
This means catastrophic floods could follow if the hurricane stalls inland. And with the Appalachian Mountains to the west, there could be flooding and mudslides, experts worry.
Governor Nathan Deal has issued a state of emergency for all 159 counties in Georgia as Hurricane Florence makes its way toward the east coast.
A number of other businesses, including Sam's Club, Lowe's, and a range of local retailers across North Carolina and SC, were shut down or were planning to shut down ahead of the storm.
As of Tuesday, about 1.7 million people in North and SC and Virginia were under warnings to evacuate the coast, and hurricane watches and warnings extended across an area with about 5.4 million residents.
The US National Weather Service says more than 10 million residents in the US states of South Carolina, North Carolina and Virginia are under a storm watch or warning because of Hurricane Florence.
Described as a monster, the eye of Hurricane Florence continues to grow.
Some airlines will allow you to change your flights for free while waiving fees for baggage and pets or even offering refunds. "It's going to happen".
"We just feel pretty secure with everything". In South Carolina, Beaufort County Emergency Management Division Commander Neil Baxley told residents they need to prepare again for the worst just in case.
A photo of George Brown, 90, is pinned to his shirt along with personal information before he is evacuated with fellow residents from a healthcare home in Morehead City, N.C., on Wednesday as Hurricane Florence approaches the east coast.