He made it clear that he believed China was aiming at unseating President Trump in response to his policies on trade. As proof, Trump later referenced a paid advertising insert in The Des Moines Register by Chinese government-affiliated entities.
Pence pointed directly to news coming out about a burgeoning "trade war" between the United States and China.
"It is very ridiculous for the USA side to stigmatise its normal exchanges and cooperation with China as China interfering in its internal affairs and elections", Hua said.
In what was billed as a major policy address, Mr Pence sought to build on Mr Trump's speech at the United Nations last week in which he alleged that China was trying to interfere in U.S. elections.
While the vice president stressed the threats posed by China to American interests, he emphasised that the USA desires a productive relationship with Beijing.
Pence alleged China was waging a sophisticated effort to sway the November 6 elections against Trump's Republican Party in retaliation for his trade policies against Beijing and vowed to continue to expose Beijing's "malign influence and interference".
Trump signed an executive order in September authorizing sanctions against those found to be involved in election interference, but USA officials have said repeatedly they have not seen almost the same level of activity by Russian Federation and others in the midterms as in 2016.
Pence's speech comes amid rumors that the US military is proposing a "major show of force" near China's territorial waters in November - "several missions" over the course of a week to demonstrate American naval and air superiority within striking distance of mainland China. Pence's speech marks a more aggressive line on China than the Trump administration has held previously, perhaps bolstered by Trump's recent success with rewriting NAFTA. "It's using wedge issues, like trade tariffs, to advance Beijing's political influence".
Pence also warns American businesses to be vigilant against Chinese efforts to leverage access to their markets to modify corporate behavior to their liking.
Despite that, Pence said, "As a senior career member of our intelligence community recently told me, what the Russians are doing pales in comparison to what China is doing across this country".
"In one recent example, they threatened to deny a business license for a major USA corporation if it refused to speak out against our administration's policies", the text said, without specifying the company.
Pence also said China had deployed anti-ship and anti-air missiles on islands it is building in the disputed South China Sea, despite promises not to militarize them.
In excerpts of his speech seen by reporters, Pence was also to call attention to an incident in which a destroyer, the USS Decatur, traveled within 12 nautical miles (22km) of the Spratly Islands (Nansha Islands, 南沙群島) on Sunday.
He warned Beijing that the United States "will not be intimidated" and "will not stand down".
"The United States Navy will continue to fly, sail and operate wherever worldwide law allows and our national interests demand", he said.
The PBS NewsHour will update this story as it develops.