Key undecided senators - as well as congressional leaders - have been receiving the majority of the protests, in particular key remaining undecided senators Republican Susan Collins of ME and Democrat Joe Manchin of West Virginia. Lisa Murkowski voted against moving the nomination forward, also announcing she will vote against confirming Kavanaugh.
Brett Kavanaugh's elevation to the US Supreme Court is all but assured.
Acrimonious to the end, the battle featured a climactic roll call that was interrupted several times by protesters in the Senate galleries before Capitol Police removed them.
A lone Democrat, Joe Manchin, voted in favour of advancing the process on Friday morning, but had not yet stated his position on the final vote.
Republican Susan Collins and Democrat Joe Manchin, both regarded as swing votes, said they would support Kavanaugh. Daines' calendar to walk Annie Daines down the aisle long before the contentious Senate brawl over Kavanaugh's confirmation.
Senate Minority Leader Chuck Schumer, D-NY, accused Kavanaugh of being evasive in his answers during his confirmation hearings on key topics.
Manchin said he had reservations about Kavanaugh because of the sexual misconduct allegations against him "and the temperament he displayed in the hearing".
Ultimately, it was Collins who put Kavanaugh on the brink of a lifetime appointment.
Republicans said the secret document _ which described interviews agents conducted with 10 witnesses _ failed to find anyone who could corroborate allegations by his two chief accusers, Christine Blasey Ford and Deborah Ramirez. Protesters marching arm in arm from the Supreme Court to Senate office buildings Thursday wore shirts that said "Believe women" while chanting "Hey hey!" "We must always remember that it is when passions are most inflamed that fairness is most in jeopardy".
The Kavanaugh fight has riveted Americans just weeks before November 6 elections in which Democrats are trying to take control of the U.S. Congress from the Republicans.
Murkowski acknowledged she agonized over her vote, telling reporters she didn't make up her mind until she walked into the Senate chamber. He praised her for "extending an olive leaf branch" to the Democrats at the same time that she dismantled their arguments.
Senator Manchin, the only Democrat to support Kavanaugh, made the announcement soon on the Senate floor.
It's not a huge surprise that Manchin voted for Trump's nominee considering he's running for reelection in a state the president won by almost 42 percentage points over Hillary Clinton in the 2016 election. He is up for re-election in West Virginia, a state Trump won overwhelmingly in 2016. But he said he will because he considers Kavanaugh a "qualified jurist who will follow the Constitution". People shouted "shame, shame" as Manchin spoke to reporters about his decision.
That left unclear whether Friday's tally signaled that the 53-year-old federal appellate judge was on his way to the nation's highest court, though it would be unusual for lawmakers to switch their votes on such a high-profile issue.
Tensions were also reflected by the thousands of boisterous anti-Kavanaugh demonstrators who flowed around the Capitol complex for days, confronting senators and even reported near their homes.
Senator Collins appeared to fall in line with Mr Trump's accusation that outside funding was being pumped into the process, as she slammed the "unprecedented amount of dark money opposing this nomination".
Confirmation would be a crowning achievement for Mr Trump, his conservative base and Senate Majority Leader Mitch McConnell. A few Democrats sat stone-faced nearby.