The Cup had always been the nut that Sheikh Mohammed could not crack despite trying to hit it with a sledgehammer on plenty of occasions.
The 8-1 chance Cross Counter, who broke the track record when winning the Gordon Stakes at Glorious Goodwood in the summer, won by a length from the Hughie Morrison-trained Marmelo, with A Prince Of Arran third for Charlie Fellowes.
This year, Sheikh Mohammed had three runners in the Melbourne Cup, spread across his three training operations headed by Appleby and Saeed Bin Suroor in the United Kingdom and UAE and James Cummings in Australia.
Early arrivals to Flemington are expected to cop a drenching as heavy rain and thunderstorms lash Melbourne. "The horse is a very good stayer, with a mature mind for his age and experience", he added.
Irish-trained horse the Cliffsofmoher suffered a fatal injury in the race.
"This is all for Sheikh Mohammed and Godolphin, and for me to say thank you for giving me this opportunity".
"I'm just in a fortunate position to have the horses to make the call on which are the right ones to bring down here".
"He's [Cliffsofmoher] the latest in a long line of dead horses", the representative said, according to the Daily Mail.
"[Tuesday's] tragedy is a stark reminder of the risks these horses face every time they run, and highlights that behind the gloss and glamour of Cup celebrations there is a dark reality".
Moore was uninjured in the incident.
McEvoy's great triumph was also Cathy's first time seeing him win the Melbourne Cup, which he has managed to achieve on three occasions.
"It was an fantastic ride by Kerrin, win, lose or draw I always knew I had the right man on there and he had a blank canvas to go out there with", he said.
Cross Counter is also a member of a family with which Sheikh Mohammed has been involved through four generations.
The winning jockey, Australian Kerrin McEvoy now has three Melbourne Cups to his name after winning the race on Brew as an apprentice in 2000 and Almandin in 2016.
Sheikh Mohammed, the ruler of Dubai, promoted him in 2013 when trainer Mahmood al Zarooni was given an eight-year ban after a doping scandal.
But it was his win in an Ascot in a three-year-old handicap in July that made Melbourne a possibility and it was a strategy that did not disappoint.
The win Down Under was only Cross Counter's eighth run and it came only 11 months after his debut.