In Germany, federal police said there had been multiple arrests in the early morning raids on premises linked to the southern Italy-based organized crime group.
Law enforcement and judicial officials speak at a press conference organized by Eurojust in The Hague, Netherlands, on December 5, 2018.
Italian anti-mafia prosecutor Federico Cafiero De Raho said the operations would affect the 'Ndrangheta's drug trafficking operations around the world, including Colombia, Ecuador and Brazil.
Those arrested are suspected of drug trafficking, money laundering, bribery and violence, said Italian police and Eurojust, the European prosecution agency that tackles cross-border organised crime.
Hundreds of police are understood to have been involved in the operation in Belgium, Italy, Germany and the Netherlands.
Fred Westerbeke, chief prosecutor of the Dutch Prosecutor's office, said authorities seized roughly $2.27 million in the raids, along with amounts of ecstasy and cocaine. On Tuesday, Italian authorities said they had dismantled the rebuilt upper echelons of the Mafia in the Sicilian capital of Palermo by arresting 46 people, including the man presumed to have taken over as provincial kingpin.
The 'Ndrangheta mafia comes from Calabria in southern Italy.
"They are invisible", Cafiero de Raho added.
In Germany, the raids - which are part of Operation Pollino - are focused on the western state of North Rhine-Westphalia, where the mafia has traditionally had a large presence.
Among the 'ndrangheta clans hardest hit by Wednesday's raids was the Pelle-Vottari crime family, investigators said. They are accused of committing "serious crimes" including activities linked to global drug trafficking, Italian police said in a statement. There should be over 1,000 arrests and billions of euros should be seized.
The Belgian operations were concentrated on the Limburg area, home to many people of Italian descent who moved there after World War II to work in coal mines, Belgian prosecutors said.
In August 2007, 'Ndrangheta caused an worldwide uproar when six people were shot in front of an Italian restaurant in the German city of Duisburg.
Eurojust said those arrested Wednesday included "high-ranking members of the Mafia network", but didn't release their names.