But Israel launched the airstrikes after it intercepted a missile over the Golan Heights, hours after what Syria says were missiles fired near the Damascus airport.
Russian Federation has in the past taken a permissive attitude to Israeli strikes in Syria, but relations broke down after Russian Federation blamed Israel for the shooting down of an Il-20 reconnaissance plane by Syrian air defences in September previous year.
Israel Defense Forces confirmed that it attacked several of the Syrian Armed Forces' Pantsir-S1 air defense batteries around Damascus, on 21 January.
"No we will not let it happen and we are ready to face an escalation because the goal and the target is so big to prevent Iran from building independence war machine in Syria we are ready for escalation", Amidror said.
It said the missiles hit apparent Iranian and Hezbollah arms depots.
State news agency SANA said a "bomb blast" had hit southern Damascus "without leaving any victims".
Last month the IDF carried out a highly publicized operation to destroy tunnels from Lebanon into Israel it claimed were dug by Hezbollah.
The SOHR described the Israeli attack as the "most intense and violent attack against the regime forces and their allies in terms of casualties since May 2018", whenIsrael carried out a large-scale attack on Iranian targets in Syria following dozens of rockets launched from Syria toward Israel. The rockets were intercepted by Israel's Iron Dome anti-missile defense system. The ski centre was closed on Monday.
Until now Israel has largely refrained from public admissions of military operations in neighboring Syria.
It was a highly unusual retaliatory attack in response to an airstrike earlier Sunday against targets in the Damascus International Airport and in the town of al-Kiswah, south of the capital, allegedly by Israel.
Its warplanes have been targeted by anti-aircraft fire during such raids, but it has rarely faced surface-to-surface missile fire in response.
The IDF Spokesperson's Unit also said in a statement that "the Iranian attack on Israeli territory yesterday is yet another clear proof of the intention behind the attempts to establish Iran in Syria and the danger they pose to the State of Israel and regional stability".
In a telephone briefing sponsored by The Israel Project, former Israeli National Security Advisor Maj.
"We hold the Syrian regime responsible for everything taking place within Syria and warn them against targeting Israel or permitting others to target Israel from their soil", the IDF wrote.
The Golan Heights has been an area of tension between Israel and Syria for decades.
An Israeli military spokeswoman declined to comment.
More than 360,000 people have been killed and millions displaced since the start of Syria's civil war with the brutal repression of anti-government protests in 2011.