The Chiefs quarterback still managed to rack up 156 passing yards and a touchdown before his departure.
We'll be bringing you live updates of the Pro Bowl below.
The Pro Bowl returned to a conference split structure in 2016 and this year is no different, with the AFC taking on the NFC.
Each player on the AFC will get $67,000 for the victory, $8,000 more than the players who lose the Super Bowl next week in Atlanta. Chicago's Mitchell Trubisky, Minnesota receiver Adam Thielen and Prescott threw interceptions. The play ended after several laterals and even more half-hearted attempts at tackles.
And that's exactly what Chiefs fullback Anthony Sherman gave it in the second quarter of Sunday's game.
New York Giants rookie Saquon Barkley was one of those three backs, joining Alvin Kamara and Ezekiel Elliott. While those stats would be rather pedestrian in a normal game, the Pro Bowl is a rare exception.
A year ago at this time, the Kansas City Chiefs were clearing the depth chart via a trade of Alex Smith to the Washington Redskins to officially pass the starting quarterback's torch to Mahomes, allowing him a drama-free offseason to learn and lean into the role.
Several other Chiefs enjoyed solid performances in the Pro Bowl at Camping World Stadium on Sunday afternoon.