Eddie Jones has been very unlucky in recent months with injuries to his star players, and Itoje becomes the latest victim. Hopefully he'll heal fast and we'll have him back ASAP. He said: "He's going to be the best lock in the world so it's a big loss.' While some reports have suggested that the 24-year-old will be sidelined for eight weeks, sources have indicated to Sportsmail that that would be the worst-case scenario".
In terms of areas of weakness exposed by the English, Schmidt added: "We've worked incredibly hard to get to where we are without suddenly saying one game has completely undone us".
"These games have got nothing to do with the World Cup", Jones said.
"He's in your face, he's someone teams do not want to play against".
Schmidt, whose decision to play centre Robbie Henshaw out of position at fullback instead of the fit again but ring-rusty Rob Kearney did not pay off, said his players needed to change their attitude to how they approached the England game.
Losing their key second row for Sunday's fixture with France and nearly certainly Wales a fortnight later is a substantial blow to Eddie Jones's men.
"We couldn't assume we could rock up and just deliver a performance that they would accept".
"When we don't have that [variety] unfortunately we're struggling against teams of the quality of England".
"It was actually the first kick-off, I think it was Itoje twice, the first kick-off and then the one in the air", Earls explained.
During Ireland's ascent to the top of world rugby, flyhalf and 2018's world player of the year Johnny Sexton and scrumhalf Conor Murray routinely put opposing backs under pressure by booting the ball high, often profiting from ensuing fumbles as opposing backs attempted to gather before being engulfed by the Irish onrush. We were a bit off, probably physically, we didn't front up enough and lost the collisions.
"We've got to dust ourselves down, not feel sorry for ourselves. I think Murrayfield's a great place to go to try to get a win and get back on track".