Nissan's premium brand suffered a 78.7% volume decline in 2018, from 3,515 to just 750 units, despite building its Q30 and QX30 models in Sunderland, and has just six United Kingdom dealerships, following the closure of the Glyn Hopkin-run site in St Albans.
In December previous year an Infiniti spokesman told Autocar that there are no plans for it to exit the UK. Just 170 of the pair were sold in Australia previous year, with the marque notching up just 649 sales in total.
Infiniti says the decision to leave Europe will allow the company to focus on growth opportunities in North America and China.
Around 250 employees at the Sunderland auto factory are dedicated to Infiniti production.
According to Car Sales Base, the brand sold just 6250 vehicles across Europe a year ago, down from 12,571 in 2017.
In today's statement Infiniti said that the business was now working to "find alternative opportunities for any employees affected by its restructure, consulting with employee representatives where necessary and identifying opportunities for transition and training support where appropriate". Work is due to conclude in Sunderland "by mid-2019".
About 250 staff could be affected by the move and Nissan intends to discuss the impact with those employees.
Sky News reported last week that shifts at the Sunderland plant could be reduced from three to two a day and potential result in up to 400 job losses.
"In the coming weeks Unite will be working closely with Nissan to protect jobs and ensure that redeployment is carried out in an open and transparent way".
Vehicle companies are streamlining their portfolios and production sites among growing global pressures including trade wars, the costly shift to electric cars and weakening markets.
Sunderland is now the only Nissan plant building Infiniti's Q3 and QX30 models.