In a statement released on their website late on Friday, Barcelona wrote: 'Lionel Messi did not have the return to global action that he would have wanted, and an injury picked up on Friday night means he will miss Argentina's game against Morocco on Tuesday.
The 24-year-old keeper said it is an "honour" to have him return to the worldwide stage.
Regarded by some as the best player of all time regardless of his worldwide expolits, Messi is desperate to end his career with a trophy with Argentina.
Argentina's Lionel Messi returned to global duty for the first time since the World Cup on Friday but it was a disappointing night for the forward as his side lost 3-1 to Venezuela in a friendly in Madrid.
"If he wants to play with Argentina, better".
There is the caveat, however, that any potential Messi Mark 2 would have to go through the same kind of developmental process to reach the spectacular heights of the current Barcelona star, who many hail as the greatest of all time.
Argentina has a revamped squad, with several younger players who were not in the World Cup team.
Earlier on Thursday, Scaloni told a press conference he hoped the squad would "step up" to the level of their five-time Balon d'Or winning team-mate. "He hasn't been with a lot of these players here".
Lionel Messi was back for Argentina, but it wasn't a happy return for the No.10 as Venezuela won the friendly at the Estadio Wanda Metropolitano by a 3-1 scoreline.
"I've already said yes, they [Dybala and Messi] are both compatibles but we have to work it out, I'm sure we can make it within some time", Scaloni added.
After the match, Venezuela boss Rafael Dudamel said he would give up the post due to political situation that surrounds the team. The friendly match will be in the Catalan city of Girona.