"With Republicans controlling the Senate 53-47, it would take opposition from just four GOP senators to sink the nomination, presuming all Democrats will also be" no" votes.
"If I had to vote today, I would vote no", Senator Kevin Cramer said in an emailed statement.
It's possible this speculation is all wrong and that Trump will go to the mat for the former Godfather's Pizza executive, who had an active career as a right-wing talk-radio gabber in Atlanta before he went national with a 2012 presidential campaign.
Some Senate Republicans have voiced concerns over Cain's support for slashing interest rates, echoing a call by Trump.
Cramer is joined in opposition by Sens. Lisa Murkowski (R-AK), and Mitt Romney (R-UT) - depriving him of the votes he needs to be approved.
"I like Herman Cain", Trump told reporters on Wednesday. "It's important that the board be comprised of people who are academics, economists, and not people who are highly partisan".
"I think my qualifications stand up pretty well", he said.
Senate Majority Leader Mitch McConnell told members during a private lunch on Tuesday to share their concerns with the White House sooner rather than later, before Trump officially nominates Cain.
Cain served as the Chairman of the Federal Reserve Bank of Kansas City's Omaha Branch, from 1989 to 1991 and as the Chairman of the Federal Reserve Bank of Kansas City from 1995 to 1996. "But as far as I know, it hasn't been made yet". "Herman is a great guy and I hope he does well". The president has said he plans to unveil yet another conservative man, Stephen Moore, for another vacancy on the board.
President Donald Trump's pick for the Federal Reserve Board was launched in contempt of court for failing to pay $300,000 in alimony and other obligations related to a divorce, according to a report from The Guardian.
He can complain publicly, as Trump has done routinely, breaking a roughly 25-year span of presidents generally not commenting on Fed policy. "Sexual harassment is quite different". I'm not talking about his position on interest rates or anything like that, but the sexual harassment stuff. And I haven't heard an explanation.
"It is incredible that with a very strong dollar and virtually no inflation, the outside world blowing up around us, Paris is burning and China way down, the Fed is even considering yet another interest rate hike".