"We need to score goals", Solskjær said.
"Sometimes people have said to me it has to be our year because of 20 years ago and being back at the Nou Camp but to go through, we have to perform and have to deserve it. I expect them to be ready".
Chilean forward Sanchez, who scored 47 times in 141 appearances with Barca between 2011 and 2014, has not featured since picking up a knee injury against Southampton last month, while Matic is recovering from a muscle injury.
Marcus Rashford and Romelu Lukaku are the two players who are expected to start up front on Tuesday at the Camp Nou and there is a slight possibility that Sanchez is brought on late in the second leg if Solskjaer is planning to throw the kitchen sink at Barcelona.
Matic's return is also timely given the hard run in to the end of the season for United. We're challenging for a semifinal.
The Red Devils were criticised by some for their cautious approach to playing Barcelona in the first leg and Solskjaer is hoping for a better performance this time out.
The United manager will return to the scene of his winning goal in the 1999 Champions League final against Bayern Munich. "It's about confidence and being focused. We know we'll create chances, we have a goal threat - it's about taking a deep breath and taking those chances". "They say "it was the best night of my life but don't tell my wife" - that kind of thing".
'I think the only away game they have not won so far was away to Valencia so the tie is still open'. "If we get the first goal it would be so important". "Sometimes it's quality [that counts], sometimes it's David de Gea at the other end".
"We had (Barcelona) flustered at times here as well".
"You have to stand up for yourself against big boys because you're going to play against top players in the world and then you can't look round and always ask for help".
Two of those games were at Juventus and Paris Saint-Germain and the one they lost in Valencia was when they were already through the group stage. We put in many, many, many crosses but Gerard Piqué and Clement Lenglet defended really well so that might not be the way to break through. We weren't good enough at home.