Pompeo flew to Saudi Arabia and the United Arab Emirates to meet their leaders days after Iran shot down a USA spy drone, prompting President Donald Trump to order and then cancel a retaliatory strike. He was meeting with his Russian and Israel counterparts in a first-of-its-kind trilateral security summit in Jerusalem that was focused on Iranian involvement in regional conflicts, particularly in neighboring Syria.
Mr Pompeo's visit to Abu Dhabi followed a meeting in Saudi Arabia with King Salman and came as US President Donald Trump called on consumers of oil from the Middle East to take greater responsibility for protecting shipping lanes such as the Strait of Hormuz.
Pompeo was greeted upon his arrival on Monday in the Red Sea city of Jiddah by new U.S. Ambassador to Saudi Arabia John Abizaid and Saudi Foreign Minister Ibrahim al-Assaf.
The crisis gripping the Middle East stems from Trump's withdrawal of the USA a year ago from the nuclear deal with Iran and other world powers and then imposing crippling new sanctions on Tehran.
"The UAE strongly condemns this terrorist act and labels it as new evidence of the Iranian-backed Houthi militias' hostile and terrorist tendencies to undermine security and stability in the region", said a statement by the Ministry of Foreign Affairs and International Cooperation.
The US has sought to end all of Iran's oil exports, one of a series of unilateral sanctions that Tehran has described as "economic terrorism".
Trump last week ordered but then cancelled a military strike on Iran, saying the response would not be proportionate to shooting down an unmanned drone.
"The president is keen on sharing that the United States doesn't bear the cost of this", Pompeo said.
Citing unspecified Iranian threats, the US has sent an aircraft carrier to the Middle East and deployed additional troops alongside the tens of thousands already there.
According to Saudi military, Houthis attacked the Abha airport just after 9 p.m. local time.
The Security Council issued a statement condemning the latest attacks on oil tankers and urging all parties "to exercise maximum restraint and take measures and actions to reduce escalation and tension".
Riyadh has repeatedly accused Iran of supplying sophisticated weapons to the Huthis, who have launched cross-border attacks on facilities inside Saudi Arabia.
The list of wounded people includes 13 Saudi citizens, four Indian expatriates, two Egyptians and two Bangladeshis.
An Iranian admiral said their military stood ready to shoot down any other US drones that might encroach on their territory.
Mike Pompeo traveled from Washington to Saudi Arabia on Sunday to begin a set of hastily arranged meetings created to push back against what he calls the world's largest state sponsor of terror.
Mr Hook said the U.S. would lift sanctions against Tehran if there were a new nuclear deal, but said any deal must come first.
Pompeo used rare emergency powers, citing Iran as a threat, to authorise $8.1 billion in weapons sales to Saudi Arabia and the United Arab Emirates, despite concerns in the US Congress that the arms will go to kill civilians in the devastating war in Yemen.