Chasing her eighth Wimbledon victory in her second consecutive final at the All England Club, Serena will face Simona Halep on Saturday for her shot at a 24th Grand Slam title, which would tie Margaret Court's all-time record.
Williams destroyed Barbora Strycova in the semifinals, winning 6-1, 6-2 in just 59 minutes.
Standing in her way is 27-year-old Romanian former world number one Halep, who says she has a new-found love of grass courts and a belief she can beat anyone and win a second Grand Slam title.
"It definitely feels good to be back in the final, especially after my year", said Williams, who only played 12 matches during an injury-ravaged 2019 season before arriving in London. "It's just about going out there and giving my best effort, no matter what".
"About 10, 15 years ago she said her dream is to (see me) play a final in Wimbledon because everyone is here, (including the royals and the celebrities who sit in) the Royal Box (on Centre Court)", said a beaming Halep.
For anyone, really, when Williams is at her best. The French Open has been her most successful major with three final appearances - including a win in 2018. In the Open Era, only 10 other players have pulled this feat off, with Chris Evert having done it the most times with six and Williams now tied on four with Stefanie Graf. I was really pumped, it was for a place in the semis at Wimbledon and that doesn't happen every day.
"The biggest key with our matches is the loss that I had. Her daugher is here and she is pain free now for three weeks so she feels so much lighter".
This is the first time Strycova has reached the semi-finals of a Grand Slam after she stunned Britain's Jo Konta in the quarter-finals.
"Looking back, to even be in those two finals last year was unbelievable", the 37-year-old told reporters.
And last September, again the red mist came down across her furious and disbelieving eyes as she railed against the perceived injustice heaped on her by the chair umpire Carlos Ramos and lost in the most theatrical exit.
When Sabine Lisicki lost the final at Wimbledon to Marion Bartoli in 2013, she could not control the flow of tears that showed her desolation. After Williams won the fourth game of the set, Strycova was in position to take the fifth game, before a double fault at 30-30 and an easy unforced error at the net for game point gave Serena the lead.
"I'm desperate to win Wimbledon more than to stop her". We all know that.
Ahead 2-1 in the first set while Strycova served at 30-all, Williams sailed a backhand return way long and let out a cry of "Aaaaah!"
Woods and Williams are close friends.
From that point, the match appeared little more than a formality, but one suspects that Halep's relentless pace will provide more of a challenge to the American as she attempts to carve out her own piece of history on Saturday.