She added: "The trust you placed in me is confidence you placed in Europe; your confidence in an united and strong Europe from east to west, the south to north; your confidence in a Europe that is ready to fight for the future rather than fighting against each other".
"If she becomes the first woman to lead the European Commission, that will make her proud, but she won't see it through the gender perspective but from the point of view of a politician who wants to solve the real problems".
The Christian Democrat of the European People's Party was a last-minute candidate to succeed Jean-Claude Juncker that EU leaders agreed as part of a package of top jobs that were decided on early this month.
Ahead of Tuesday's vote on her nomination in the European Parliament, von der Leyen's sentiment was markedly more cautious than her previous statements on Brexit, which she has referred to as a "burst bubble of hollow promises".
Warnings have multiplied since 2015, when 195 countries meeting in Paris sealed a landmark agreement to keep temperature rises well below two degrees Celsius (3.6 Fahrenheit) compared with pre-industrial levels.
"Though I am losing a long-standing minister, I am winning a new partner in Brussels", Merkel said, via her spokesman Steffen Seibert on Twitter.
Her stance seems to have impressed French President Macron in particular, who has repeatedly praised her for having "the DNA of the European community" and lauded her for her cooperation on Franco-German defence issues. A total of 327 lawmakers voted against her and 22 abstained. As a result, von der Leyen's pledges may be hollow - a decision on an extension of the deadline can only be made with their consent, and moreover she'd only take office 1st November, the day after the deadline elapses.
Who is Ursula von der Leyen?
The German Defence Minister has previously signalled her support for proposals for a new net zero target for the bloc, but in new letters to the Socialist and Liberal blocs of MEPs she sketched out plans to beef up the EU's climate strategy on multiple fronts.
German Chancellor Angela Merkel congratulated von der Leyen, calling her a "committed European" who would "tackle with great vigor the challenges facing us as the European Union".
Von der Leyen said she would be open to Brexit being delayed further "for a good reason" although she insists that the withdrawal agreement will not be renegotiated.
But she must win the backing of a majority of MEPs at a secret ballot due to take place tomorrow in order to become the first female president of the European Commission.
As well as EPP votes, Ms Von der Leyen will also need to convince socialists and liberals to vote for her tonight.
The European Parliament will hold committee hearings in September to grill commissioner nominees, such as Ireland's Phil Hogan, and judge if they are up to the task.
Juncker, for comparison, had the support of 422 MEPs, out of the needed 376 votes, during his election to the same post on 15 July 2014.
In Strasbourg, Nigel Farage, the Brexit Party leader, accused Mrs von der Leyen of wanting to build "a centralised, undemocratic, updated form of communism where nation state parliaments will cease to have any relevance at all". Sources from the S&D group estimated that 75% of the centre-left MEPs have supported van der Leyen. "Here, Ursula von der Leyen is blank".
Conversely, she also obtained support from what could be described as the opposite camp.