Williams has dominated Sharapova, winning 19 of 21 meetings. She became the first Australian to lift the trophy at Roland Garros since Margaret Court in 1973.
That is no longer the case.
Defending champion Djokovic, seeking a 17th career Grand Slam title, has won four of the past five Slams, denied only by Nadal's French Open win in June.
Before becoming an umpire, Ramos was a player but not one whose abilities could indulge his interests. Earlier this month, Williams withdrew from the Cincinnati Masters, and her final match of the Rogers Cup in Toronto both due to a back injury.
Williams has since apologized to Osaka but that does not mean she will take it easy on the Japanese if their paths cross in NY again.
"I am a little anxious about her fitness if she's going to keep getting injured but I love her game", said Evert. That's what I kind of have to deal with every day. He has drawn a qualifier and will only know his opponent once Friday's qualifiers are played. The match often won before it had even begun. "You look at your section to see who is in there".
The last 12 months have been an emotional rollercoaster for Williams, filled with rage and tears.
The umpire at the centre of last year's US Open final storm involving Serena Williams storm has been formally told he will be kept away from her matches over the next fortnight. "Playing well in slams recently, which has been great", said Federer.
With aborted runs at Indian Wells, Miami and Rome - with Williams picking up a single match win at each event - it seemed as if the glory years were well and truly behind her.
It marked the third straight year in which the "Big Three" had swept the grand slams, a feat they are looking to repeat 11 years later.
"I have to win my matches to have an advantage because I only can meet them in the semi-finals", said Nadal.
There once was no template, no game plan to beat Williams.
Top-ranked defending champion Novak Djokovic launches his bid for his fifth title in six Grand Slam events after that against Spaniard Roberto Carbella Baena.
"This is probably the best I've felt in years coming into the U.S. Open again, which is encouraging", said Federer. "I should just focus on my game".
"I'm very much aware of how I need to approach this tournament mentally".
As for Britain's Johanna Konta, the Sydney-born player appears to have completely lost confidence since suffering a shock quarter-final defeat at Wimbledon to doubles-specialist Barbora Strycova of the Czech Republic. I am practicing well during the whole week. At the same time I was caravanning with my kids.