The Hammers will feel that this is their best chance to defeat the Red Devils at home and leapfrog them in the table as both teams are on 8 points after 5 matches.
Manchester United manager Ole Gunnar Solskjaer insists he is not anxious about the form of Marcus Rashford, despite the striker struggling to score from open play. Pellegrini is an obstacle for many a Manchester United manager, having managed to win a Premier League fixture against three different United managers - David Moyes, Louis van Gaal and Jose Mourinho.
It was incredibly predictable and West Ham did exactly what they needed to do. Four of the club's five most expensive acquisitions have arrived in that 18-month period.
The Spain global could face compatriot Pablo Fornals at the London Stadium and he expects that the former Villarreal star still will be a big player for West Ham, despite him having only made one Premier League start so far this season.
Ferdinand certainly has a point, but United will have to turn things around sooner rather than later.
The East London outfit were at least solid at the back.
West Ham appeared to mock a song Manchester United fans sing about Solskjaer by posting a picture of their manager Manuel Pellegrini under the words "at the wheel".
West Ham usually line up in a 4-1-4-1 with Lanzini one of the two "eights" alongside Mark Noble, a position that allows him to roam into space protected by his midfield partner and Declan Rice in a holding role further behind.
Midfielders Tahith Chong and Angel Gomes were also handed first starts as United named their youngest European line-up since 2012. The 17-year-old is starting to stake his claim for a regular berth spearheading Solskjaer's attack.
Injuries have left Solskjaer particularly short up front but after defeat to West Ham, Solskjaer defended his decision to let Alexis Sanchez sign for Inter Milan on loan following the close of the Premier League transfer window after already selling Romelu Lukaku to the Italian side earlier in the summer. Thus, making the options for Ole Solskjaer even more slim in attack.