Goals from Paulo Dybala and Gonzalo Higuain saw Juve move a point clear of Inter, who saw their flawless start to the league season snapped by the Bianconeri.
It showed that spirits in the Turin side were sky high, and the post-match comments of Inter boss and former Juve legend Antonio Conte will only serve to inspire them further.
Lautaro Martinez cancelled out Paulo Dybala's opener with a penalty in the 18th minute and the match looked to be heading for a device.
The result sees Inter drop to second spot, just a point behind the Bianconeri.
Conte - who kick-started Juve's run of eight straight titles by delivering the first three - came out second best against his former side.
It was the Nerazzurri's first league loss of the season and took Juventus back above them in the table by one point going into the global break.
'We entered the game with a good approach, and we deserved to win'.
While it became once no longer the he would be pleased hoped for, Lukaku can be in a enviornment to determine on some comfort from the truth he made Matthijs de Ligt gape barely silly in the first half of.
The Belgian has scored three targets since his £74million transfer from Manchester United and may have been determined so as to add to his tally towards Juve, however Gonzalo Higuain stole the headlines with a late victor for the Serie A champions.
"Juve is in another category from all points of view, we can not compare to them", Conte admitted.
Ronaldo seemed to have Juve back ahead four minutes to halftime, but the effort was disallowed after the Video Assistant Referee ruled Dybala strayed into an offside position.
Gian Piero Gasperini's Atalanta celebrated moving back to the newly-named Gewiss Stadium with a 3-1 win over promoted Lecce that keeps the Bergamo side third on 16 points.
"We want to fight for the Scudetto, but our ranking makes us cry a little", said Napoli coach Carlo Ancelotti.
"Sick and exhausted of this crap costing us games".
And Dybala stated at the final whistle: "A kind of revenge for me?"
Bologna and Lazio played out an eventful 2-2 draw that saw two red cards and a missed penalty. Fiorentina beat Udinese 1-0.