Arizona backup running back Chase Edmonds is also inactive with a hamstring injury. Instead, the Niners scored on the next play, took a 21-7 lead at halftime and made the Cardinals' comeback all the more hard.
Arizona Cardinals wide receiver Andy Isabella (89) runs for touchdown after the catch as San Francisco 49ers cornerback Jimmie Ward (20) pursues during the second half of an NFL football game, Thursday, Oct. 31, 2019, in Glendale, Ariz. When you consider how much fantasy RBs have struggled against the 49ers' defense, there are some serious start-or-sit decisions to make for the first game of the week.
Listen to the latest from Cards Wire's Jess Root on his podcast, Rise Up, See Red. Jeff Wilson was stopped on a running play on fourth down from the 1-yard line with four seconds left, but Arizona coach Kliff Kingsbury had called a timeout just before the play. Being a monster on Halloween, Kittle turned that slant into a 30-yard touchdown via a nasty stiff-arm on safety Budda Baker and a leap into the end zone. Letting the clock run down to four seconds, San Francisco coach Kyle Shanahan chose to go for it at the Cardinals' 1, leading 14-7.
The 49ers took a 21-7 lead into halftime and ended up needing the touchdown in a 28-25 victory. In total, he completed 28 of 37 passes for 317 yards and a 136.9 passer rating, also a career-high. That gave the 49ers another chance, and they scored the touchdown.
"I wanted to get a Kodak timeout, one of those looks at it", Kingsbury said, via ArizonaSports.com.
With all of the uncertainty at running back, as well as the lack of viable options in the lowest salary tier on DraftKings, deviating from jamming in as many RBs as possible and instead optimizing for value looks like the best bet on this slate. "I think when we play our best ball, it's very clear what we are capable of".
San Francisco converted three third downs - one confirmed on review - and ground out the final 4:53 to remain undefeated. All three players have been with the team less than two weeks.