Washington has reimposed sanctions aimed at halting all Iranian oil exports, saying it seeks to force Iran to negotiate to reach a wider deal.
The announcement about Iran's nuclear program came as protesters marked the 40th anniversary of the Tehran hostage crisis.
"I think that for the first time, Iran has decided in an explicit and blunt manner to leave the JCPOA, which marks a profound shift", said Macron, who has been at the forefront of efforts by European signatories to salvage the deal after the United States withdrew.
The United States also sanctioned Iran's Armed Forces General Staff, the department said in the statement, which came 40 years after Iran seized the U.S. embassy in Tehran, taking more than 50 Americans hostage.
Iranian students climb over the wall of the United States embassy in Tehran 04 November 1979.
French foreign ministry spokeswoman Agnes von der Muhll said it went against the nuclear deal, adding: "We are waiting with our partners for the next IAEA reports on Iran's announcements and actions".
"Last week Iran did not allow the entrance of one of the IAEA's inspectors to the uranium enrichment facility in Natanz", the AEOI said.
Iran has already breached the deal's limits on the purity to which it enriches uranium, its stock of enriched uranium and its ban on using advanced centrifuges for enrichment rather than research, each step raising pressure on the remaining parties to the deal aiming to prevent its total collapse.
Visiting Iran's underground Natanz enrichment facility, Salehi dramatically pushed a button on a keyboard to start a chain of 30 IR-6 centrifuges as state television cameras filmed, increasing the number of working centrifuges to 60. Lindsey Graham, R-N.C., and Ted Cruz, R-Texas, issuing a rare rebuke of the president and saying, "Iran is now openly violating the nuclear deal and stockpiling risky nuclear material".
There was no immediate reaction from the White House to Rouhani's comments.
"We support the preservation of this deal", presidential spokesman Dmitry Peskov told reporters in Moscow.
The suspension of all uranium enrichment at the underground Fordow plant south of Tehran was one of the restrictions Iran agreed to in 2015 in return for the lifting of worldwide sanctions.
A brief thaw in decades of antagonism between Tehran and Washington brought about by the 2015 deal ended past year when U.S. President Donald Trump withdrew from the accord, under which Iran had agreed to rein in its disputed enrichment program in exchange for relief from economic sanctions.
Iran's Supreme Leader Ayatollah Ali Khamenei, the final decision-maker in all state matters, ruled out talks with the United States in his latest speech. "We should be able to sell our oil and to transfer its money into the country", Rouhani said, referring to USA sanctions on Iran's oil and banking sectors.