Portugal demolished their counterparts at the Estádio Algarve on Thursday, November 14, to move one step closer to Euro 2020 qualification thanks to Ronaldo's messianic presence on the pitch.
Pizzi, Goncalo Paciencia and Bernardo Silva were also on target for Portugal, who can seal second place in Group B if they beat Luxembourg in their final qualifier on Sunday.
The reigning European champions remain second in Group B, a point better off than Serbia - 3-2 winners over Luxembourg - ahead of the final round of qualifying fixtures.
"I knew he (Ronaldo) was able to play", Portugal coach Fernando Santos told Portuguese TV channel RTP. "I never had any doubts about his condition, it was other people who had them".
Ronaldo has now scored 98 global goals and will be hoping to become the second-ever player to reach 100 this weekend. "Nothing surprises me about Cristiano".
Ronaldo opened the scoring early on from a penalty he won and curled in a second prior to half-time, before completing his hat-trick 25 minutes from the end.
The 34-year-old picked up the ball outside the area and unleashed a lovely long ranged effort that bent past Ernestas Setkus in the Lithuania net.
Having been in the headlines for his reaction to being substituted in Juventus' recent match against AC Milan, Ronaldo responded in the ideal manner by putting Lithuania to the sword in clinical fashion.
Pizzi scored in the 52nd, Paciencia added to the lead in the 56th and Silva got on the board in the 63rd.